Effects of ovarian hormone on 5-HT_3 receptors mRNA expression in the rats colon
- VernacularTitle:卵巢激素对大鼠结肠组织5-羟色胺受体3的影响
- Author:
Tianjin LI
;
Baoping YU
;
Long XU
- Publication Type:Journal Article
- Keywords:
ovariectomy;
5-HT 3 receptors
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effects of ovarian hormone on th e expression of 5-HT 3 receptors in the rats colon. METHODS24 adult female SD rats were randomly divided into three groups:sham operation(Sham ) group;ovariectomy(OVX) group and ovariectomy with estrogen and progesterone(OV X+E 2+P) group. The 1 hour fecal pellets and the time of glass pellets output w ere observed 4 weeks after operation;and the expression of 5-HT 3 receptors mR NA in the colon tissues was studied by RT-PCR. RESULTSIn contra st with the Sham group and OVX+E 2+P group,OVX group showed increase in the fec al pellets output and decrease in the time of glass pellets output(P
