Effect of grape seed proanthocyanidin on the lipid profile of atherosclerosis in rabbits
- VernacularTitle:葡萄籽原花青素对动脉粥样硬化兔血脂的调节作用
- Author:
Yabing MA
- Publication Type:Journal Article
- Keywords:
grape seed;
proanthocyanidin;
lipid profile;
atherosc lerosis;
insulin resistance
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo observe the effect of grape seed proanthocyanidi n (GSP) on the lipid profile of atherosclerosis in rabbits. METHODS24 male New Zealand rabbits were randomized into three groups with 8 rabbits in each group. They were individually housed in metal cages in an air-condition ed room. Throughout the experimental period, they were given restricted amounts of food (100～120 g/head per day) of each diet, with no limit of drinking. The c ontrol group (group A) were fed with standard diet. The cholesterol group (group B) was fed with standard diet containing 1% cholesterol. The GSP group (group C ) were fed with standard diet containing 1% cholesterol plus 1% GSP. All the rab bits were fed for twelve weeks. Blood samples were drawn from ear middle arterie s of rabbits just before the experiment and at the first, the second, the forth, the eighth and the twelfth weekend of the experiment. All the rabbits were fast ed for at least eight hours before the blood was drawn. The blood samples were a nalyzed for total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) , triglyceride (TG), and high density lipoprotein cholesterol (HDL-C) and they were measured enzymatically by automatic facilities. Aorta samples were observed through optical microscope. Results were expressed as means ?s. The Mixed Procedure of SAS 8 2 software was used to evaluate the differences betwee n the cholesterol group and the GSP group. RESULTSCompared with the group B, the TC,LDL-C,TG and the TG/HDL-C were lowered markedly by dietary GSP at the twelfth weekend (P
