Influences of hesperidin on the regulation of serum lipids levels by simvastat in and CYP4503A mRNA expression
- VernacularTitle:橙皮苷对辛伐他汀调脂作用及细胞色素P4503A mRNA表达的影响
- Author:
Hongling LU
;
Minzhang QIAN
- Publication Type:Journal Article
- Keywords:
hesperidin;
simvastatin;
cytochrome P4503A;
regulatin g serum lipids levels
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the influences of hesperidin on the regula tion of serum lipids levels by simvastatin and its mechanism. METHODS Wistar rats were divided randomly into five groups:control group,model g roup,simvastatin group(SV group), low dose hesperidin +SV group(LDHS group) and high dose hesperidin+SV group(HDHS group).The control group were fed with common diet. The model group were fed with high lipid diet. Other groups were fed with diet containing high lipid,5 mg?kg -1 SV and different doses of hesperid in accordingly. After 8 experimental weeks,the serum lipids levels and CYP4503Am RNA expression in livers and small bowels of the rats were detected. RE SULTSAfter 8 weeks of high lipid diet, the levels of TC,TG and LDL-C in model groups increased significantly (P
