Influence of hyperuricemia and uric acid nephropathy in rats administrated hushentongfengjiaonang
- VernacularTitle:虎参痛风胶囊对高尿酸血症及尿酸性肾病大鼠的影响
- Author:
Wenchong SONG
;
Yaqin WANG
;
Chao CHEN
- Publication Type:Journal Article
- Keywords:
hyperuricemia;
uric acid nephropathy;
Hus;
uric acid( UA);
renal function
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo evaluate the influence of serum UA level and ren al function of hyperuricemic rats administrated Hus. METHODSHype ruricemia and uric acid nephropathy in rats were induced by adenine ig feeding f eeds containing 10% yeast Drug therapy was given Simultaneously. After 18 d, blo od of rats was drawn from the hearts. Total protein, albumin(A), A/G ratio, uric acid(UA), creatinine(Cr), urea nitrogen(BUN), triglycerides (TG), high density lipoprotein (HDL), and Cholesterol of serum were detected by automatic biochemis try analyzer. Ultrastructural alteration and UA crystal were observed. R ESULTSSerum UA, Cr, BUN of Hus groups and All group were significantly r educed compared with model group(P
