Effects of puerarin on pulmonary vascular structure of chronic hypoxia in rats
- VernacularTitle:葛根素对慢性低氧性肺动脉高压大鼠肺血管重构的影响
- Author:
Xiaofang FAN
- Publication Type:Journal Article
- Keywords:
chinese herbal medicines;
hypertension,pulmonary;
hypox ia,chronic;
collagen
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effects of puerarin on pulmonary vascular structure in pulmonary hypertension rats induced by chronic hypoxia. METHODSThirty male spragu-dawley rats were randomly divided int o three groups:control group(NC), hypoxia group(HH), hypoxia+puerarin group(HP). Collagen Ⅰ, Ⅲ and collagen I mRNA were observed in pulmonary arterioles by th e technique of immunohistochemistry and in situ hybridization. RESULTS①mPAP was much higher in rats of HH group than that of NC group(P0 05). ②The contents of lung homoge nates SOD and MDA of HP group were obviously higher than those of HH group(P 0 05). CONCLUSIONPuerarin can improve pulmonary vessel remodeling.
