Influence of rofecoxib, a high selective cox-2 inhibitor,on articular cartilage of rats
- VernacularTitle:高选择性环氧化酶-2抑制剂罗非昔布对大鼠关节软骨的影响
- Author:
Xi LIANG
;
Hong AN
- Publication Type:Journal Article
- Keywords:
non steroid anti inflammatory drugs (NSAIDs);
cartilage;
osteoarthritis;
rofecoxib;
proteoglycan;
chondrocyte
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the influence of rofecoxib, a non steroidal anti inflammatory drug, administrated for a long term on the knee joints cartilage of rats. METHODS: An experimental model of osteoarthritis of left knee in the early stage was induced by cutting achilles tendon in rats, the right knee providing a control. The rats of one group were given rofecoxib orally, and the rats in another group were given saline as a control. After 100 days, the histopathology, ultrastructure, and histochemistry changes on the knee joints cartilage were monitored. RESULTS and CONCLUSION: Rofecoxib, administrated for 100 days, had no harmful influence on chondrocyte and collagen, and could increase proteoglycan of cartilage in some degree in rats.
