DNA microarray analysis of genome dynamics in Yersinia pestis: insight into bacterial genome microevolution and niche adaptation
- VernacularTitle:鼠疫耶尔森菌基因组进化与生态位适应研究
- Author:
Dongsheng ZHOU
;
Yanping HAN
;
Yajun SONG
- Publication Type:Journal Article
- Keywords:
Yersinia pestis;
DNA microarray;
genome microevolution;
niche adaptation
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the genome dynamics of Y. pestis and look for the relationship between its genome microevolution and niche adaption.Methods The DNA microarray combined with PCR was used to perform comparative genomic analysis of natural populations of Y.pestis.Results It was revealed that considerable genome dynamics of Y. pestis were the result of gene acquisition and loss in genome. We established a genomotyping system to group homologous isolates of Y. pestis, drew an outline of parallel microevolution of the Y. pestis genome, and established the link between the bacterial niche adaptation and genome microevolution.Conclusion The transmission, colonization and expansion of Y. pestis in natural foci are the results of its parallel, directional and gradual adaptation to the complex interactions among the environment, the hosts, and the pathogen itself.
