Competitive inhibition of adherence of ETEC and EPEC to intestinal epithelial cells by purified adhesin of bifidobacterium adolescentis 1027
- VernacularTitle:双歧杆菌纯化黏附素对ETEC和EPEC黏附肠上皮细胞的竞争抑制作用
- Author:
Shishun ZHONG
;
Zhenshu ZHANG
;
Zhuosheng LAI
- Publication Type:Journal Article
- Keywords:
Bifidobacterium;
adhesin;
enterotoxigenic Escherichia coli;
enteropathogenic Escherichia coli;
bacterial adhesion;
intestinal epithelial cells
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe competitive inhibition of adherence of enterotoxigenic Escherichia coli (ETEC) and enteropathogenic Escherichia coli (EPEC) to intestinal epithelial cells by purified adhesin derived from bifidobacterium adolescentis 1027. Methods The number of bacteria adherent to intestinal epithelial cell line Lovo was counted and the results were analyzed by comparison. Results The purified adhesin in the concentration of 10?g/ml, 20?g/ml and 30?g/ml could significantly inhibit the adhesion of ETEC and EPEC to intestinal epithelial cell line Lovo. The higher the concentration of adhesin the higher inhibition rate was observed. Concentrations lower than 10?g/ml had no such effect. Conclusion The purified adhesin of bifidobacterium adolescentis 1027 could inhibit the adhesion of ETEC and EPEC to intestinal epithelial cell line Lovo, and the effect was dose-dependent.
