Activation of Na~+/H~+ exchange 1 and myocardial hypertrophy
- VernacularTitle:Na~+/H~+交换泵1激活与心肌肥大
- Author:
Changxun CHEN
;
Ruomin JIN
;
Yunhui SHEN
- Publication Type:Journal Article
- Keywords:
Na+/H+ exchange 1;
myocardial hypertrophy;
angiotensinⅡ;
alpha (1) adrenergic receptor;
beta (1) adrenergic receptor[WT
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Na +/H + exchanger 1 (NHE1) is a major contributor to ischemic and reperfusion injury. It is emerging that NHE 1 also contributes to myocardial hypertrophy and heart failure due to chronic maladaptive stimulation. It appears that NHE 1 may represent a common downstream mediator for various hypertrophic factor, such as angiotensinⅡ,beta (1) and alpha (1) adrenergic receptor activation. NHE 1 inhibition may be a effective new therapeutic approach for prevention and treatment of heart failure.-
