Protective effect of TGP on complete cerebral ischemia reperfusion injury in rats
- VernacularTitle:白芍总苷对全脑缺血再灌损伤的保护作用
- Author:
Wei LIU
;
Huapu WU
;
Xiaoguang ZHU
;
Liang MING
- Publication Type:Journal Article
- Keywords:
total glucosides of paeony;
cerebral ischemia reperfusion injury;
superoxide dismutase;
malondialdehyde
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protective effect of total glucosides of paeony(TGP)on complete cerebral ischemia reporfusion injury and its mechanism of action.METHODS A complete cerebral ischemia[FQ(10。46,X-WZ]- reperfusion model of rats was induced by clipping three arteries. The changes in eye colour, SOD activity, MDA contents and histopathological characteristics were observed. RESULTS TGP (TGP 10、20、40 mg?kg -1 ) markedly reduced the change of eye colour; TGP(20 mg?kg -1 ) obviously elevated SOD activity decreased and inhibited the MDA of increased contents of cerebral cortex, hippocampus and corpus striatum of cerebral ischemia reperfusion in rats; TGP(20 mg?kg -1 )possessed protective effects on the histopathological changes of ischemia cerebral tissues in rats. CONCLUSION TGP possessed obvious protective effects on the cerebral ischemia reperfusion injury, suggesting that the protective action of TGP is relative to anti-oxidative action.-
