Study of pharmacokinetics of AZT in mice by encapsulation in liposomes Containing galactosylceramide
- VernacularTitle:齐多夫啶半乳糖神经酰胺脂质体在小鼠的药动学研究
- Author:
Shu GAO
;
Longfu RONG
;
Yong JIN
;
Hongwei YAO
;
Lin GUO
;
Jun LI
- Publication Type:Journal Article
- Keywords:
galactosyceramide;
liposomes;
azidothymidine;
pharmacokinetics
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the pharmacokinetics of AZT in mice by encapsulation in liposomes Containing galactosylceramide (GalCer). METHODS AZT was encapsulated in liposomes containing GalCer and the pharmacokinetics of AZT-GalCer and free AZT were observed in mice. RESULTS Higher concentration of AZT in mice injected AZT-GalCer was found in plasma after 30 min and it was ten times as high as in mice injected with AZT. On the other hand, Ke decreased significantly from 0.037 to 0.021 h -1 , T_ 1/2 Ke increased significantly from 19 min to 35 min, and AUC was 2.77 times as high as in mice injected with AZT. CONCLUSIONS AZT-GalCer serving as a dilivery carrier could prolong the effective concentration of AZT in plasma. AZT-GalCer might have great therapeutic potential for treating AIDS.-
