Inhibitor of apoptosis proteins(IAP):Novel anticancer targets
- VernacularTitle:凋亡抑制蛋白(IAP):抗癌新靶点
- Author:
Xiuwen WANG
;
Liwu FU
- Publication Type:Journal Article
- Keywords:
inhibitor of apoptosis proteins;
IAP;
cancer;
therapy
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
An endogenous suppressor of apoptosis, the inhibitor of apoptosis proteins(IAP) plays a key role in the occurrence and progression of cancer. In recent years cancer researches have been focused on gene-specific inhibitors with IAP as the target, so as to seek gene therapeutic strategies of less toxicity and higher efficiency. As members of IAP family, survivin and livin are over-expressed in tumors. Meanwhile, Smac can directly inhibit IAP. These findings suggest a promising alternative strategy for developing novel anticancer therapies.-
