Proliferation and differentiation of the hepatic progenitor cells in human severe hepatitis
- VernacularTitle:重型肝炎肝组织中肝前体细胞增殖分化特点研究
- Author:
Zhongjie HU
;
Zhenwei LANG
;
Chenzhao SONG
- Publication Type:Journal Article
- Keywords:
Hepatitis,viral,human;
Regeneration;
Immunohistochemistry;
Liver/cytologyry
- From:
Chinese Journal of Infectious Diseases
1999;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features and the probable affecting factors of the proliferation and differentiation of the hepatic progenitor cells (HPC) and the liver regeneration in the patients with severe hepatitis(SH). Methods Liver tissues taken from 59 cases with severe hepatitis were tested for the proliferating cell nuclear antigen (PCNA) by immunohistochemistry (IHC). Meanwhile, PCNA were also detected in liver tissues of 58 cases with common hepatitis as controls. Results The percentage of cases with positive PCNA in hepatocytes in severe hepatitis (30.5%) was significantly lower than that in common hepatitis (50.0%) (P
