Study on the role of the chimeric hsp70/CD80 DNA vaccine for treating infection of Mycobacterium tuberculosis
- VernacularTitle:Hsp70/CD80嵌合DNA疫苗对结核杆菌的治疗作用
- Author:
Xiaoling SHI
;
Hui LI
;
Sen ZHONG
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Vaccines DNA;
Antigens, CD80;
Heat-shock proteins 70
- From:
Chinese Journal of Infectious Diseases
1999;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of the chimeric hsp70/CD80 DNA vaccine for treatment for TB. Methods C57BL/6N mice challenged with H37Rv were immunized with the chimeric hsp70/CD80 DNA vaccine, hsp70 DNA vaccine and BCG in order to compare the therapeutic role of these vaccines. Results The levels of interferon ? (IFN-?) in the serum of mice in hsp70/CD80 group (1336.98?129.64) pg/ml was significantly higher than in group BCG (121.54?56.39) pg/ml, pcDNA3 (192.00?64.36) pg/ml and pcDNA3 hsp70 (542.33?99.77) pg/ml. The growth of Mycobacterium tuberculosis in live and spleen were inhibited significantly in hsp70/CD80 vaccinated mice. Conclusions The chimeric hsp70/CD80 DNA vaccine was more efficient than BCG and hsp70 DNA vaccine alone in treating TB.
