Molecular mechanism of protective effects of estrogen on cerebral ischemia
- VernacularTitle:雌激素对脑缺血保护作用的分子机制
- Author:
Qian HUANG
;
Yingqing LU
- Publication Type:Journal Article
- Keywords:
estrogen;
cerebral ischemia;
neuroprotective;
cerebral blood flow (CBF);
apoptosis, estrogen receptor
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Estrogen has the protective effect on cerebral ischemia in v ar ious ways. It not only can improve the regional cerebral blood flow during ische mia and rescue the remaining neurons alive, but also can reduce the injury of is chemia-reperfusion. In this article, we enumerate at the molecular level that e strogen has the properties of inhibiting the expression of VCAM and cytokines li ke TNF-? in the ischemia region, educing the overload of calcium and cytotoxic ity of EAA by modulating the calcium channels, and regulating related genes expr ession and anti-apoptosis. It is crucial for estrogen replacement therapy as a neutoprotectant clinically.
