Comparison of energy metabolism on brain lacking oxygen between Salvia miltiorrhiza Bunge injection and Salvia przewalskii Maxim injection in mice
- VernacularTitle:甘西鼠尾草注射液与丹参注射液对化学性缺氧小鼠能量代谢影响的比较
- Author:
Huiying LUO
;
Tijuan CHENG
- Publication Type:Journal Article
- Keywords:
salvia mil tiorrhiza Bunge injection (SMBI);
salvia przewalskii Max im injection (SPMI) acute brain lacking oxygen;
Na +-K +-ATPase;
Ca 2+ -ATPase;
laitic acid
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the influence of salvia miltiorrhiza Bunge njection (SMBI) and salvia przewalskii Maxim injec tion (SPMI) on energy metabolism of acute brain lacking oxygen. METHODS : The whole brain lacking oxygen model was made by injecting NaNO 2 in mice and then wrote down the existent time of mice and detected the contents of Na +-K +-ATPase, Ca 2+ -ATPase and lactic acid (LD) in the brain. RESULTS: SMBI and SPMI both significantly lengthened the existent tim e of mice with the whole brain lacking oxygen, decreased the contents of LD and increased the activity of ATPase in mice. In increasing the activity of ATPase, the influence of SPMI was more than that of SMBI (P 0.05 ). CONCLUSION: SMBI an d SPMI have distinctive protection on energy metabolism of acute brain lacking o xygen. Both of them can lengthen the existent of mice, reduce the contents of LD in brain and increase the activity of ATPase, but SPMI is more excellent than S MBI in increasing the activity of ATPase.
