Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) be nzaldehyde benzoyl hydrazone or their complexes
- VernacularTitle:2-羧甲氧基苯甲醛苯甲酰腙及其配合物抑菌活性的构效关系
- Author:
Xingming MA
;
Yanping LUO
;
Baocheng MA
;
Rudong YANG
- Publication Type:Journal Article
- Keywords:
hydrazones compounds;
ligand;
complexes;
ba cteriostasis;
Kirby-Bauer method
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study ba cteriostasis activities of ligand (2-(carboxymethoxyl) benzaldehyde benzoyl hyd razone (H 2L)) and their complexes. METHODS: Ligand H 2L and t heir complexes were synthesized. The bacteriostasis activities of H 2L and thei r complexes in vitro were tested with K-B method. RESUL TS: 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone only showed bact eriostasis activities on Staphyloccus aureus and their complexes had dramatic bacteriostasis activity on Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Bacteri ostasis ring diameter of Cu-complex was largest. CONCLUSION: L igand H 2L complexes have bacteriostasis activities in vitro. B acteriostasis activities of Cu-complex are strongest among the complexes.
