Characterization and significance of peripheral blood dendritic cell subsets in patients with HBV-associated hepatocellular carcinoma
- VernacularTitle:HBV慢性感染相关的肝癌病人外周血树突状细胞亚群的特点及其意义
- Author:
Min WANG
;
Fusheng WANG
;
Xuezhan DUAN
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
type 1 dendritic cells;
type 2 dendritic cells;
interferon-alpha
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics and clinical significance of peripheral blood dendritic cell (DC) subsets in patients with primary hepatocellular carcinoma (HCC). Methods Twenty-six HCC patients were enrolled for study. Twenty three patients with chronic HBV infection and twenty healthy individuals were entered as controls. Peripheral blood DC subsets and lymphocyte subsets of patients and healthy subjects were analyzed by flow cytometry. Interferon-?(IFN-?) production of peripheral blood mononuclear cells (PBMC) induced by inactivated herpes simplex virus type 1 (HSV-1) was measured by a human IFN-? ELISA kit. Results Compared with healthy subjects, patients with HCC had a significantly decreased proportion and absolute number of DC1 and DC2 (P
