Early hypothyroidism after ~(131)I treatment of Graves′ disease
- VernacularTitle:~(131)I治疗甲亢后61例早发甲状腺功能减低分析
- Author:
Yi FANG
;
Jianfeng LIU
;
Youren ZHANG
- Publication Type:Journal Article
- Keywords:
iodine radioisotopes;
hyperthyroidism;
hypothyroidism
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the development of early hypothyroidism of patients with hyperthyroidism after radioiodine131 therapy, its outcome and predisposing factors. Methods Sixty-one patients manifesting early hypothyroidism after treatment with 131 I were followed-up for over one year, and they were divided into two groups: temporary hypothroidism group (including those who had attained normal thyroid function and those with recurrent hyperthyroidism), and permanent hypothyroidism. The duration between treatment and appearance of hypothyroidism, gender, thyroglobulin antibody (TGA) and thyroid microsome auto-antibody (TMA) levels, thyroid weight, total dosage of 131 I, and peak of 131 I intake were compared between two groups. Results Over one half of the 61 patients manifested temporary hypothyroidism (3.3% with recurrent hyperthyroidism, 50.4% of them attained normal thyroid function). Based on the length of the interval between the beginning of the treatment and onset of hypothyroidism, they could be categorized into ≤3 month, 4～6 months became permanent hypothyroidic. The above indises determined during the treatment did not show relationship with the outcome. Conclusion It was therefore concluded that the time of appearance of hypothyroidism was the main factor which determined the outcome of 131 I therapy so far as hypothyroidism was concerned.
