Apoptosis and expression of PCNA and distribution of TUNEl positive cells in human vulnerable atherosclerotic plaque
- VernacularTitle:冠状动脉不稳定斑块中平滑肌细胞和炎性细胞PCNA阳性及TUNEL阳性细胞分布特点
- Author:
Changqing FAN
;
Ye TIAN
;
Wei YANG
- Publication Type:Journal Article
- Keywords:
Vulnerable plaquePCNAApoptosis
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the roles of apoptosis and express io n of PCNA in human vulnerable atherosclerotic plaque.MethodsAp optosis was detected by TUNEL.Expessions of PCNA were detected in samples of vul nerable plagues From 23 cases of coronary heart disease.by SP immunohistochemica l technique.ResultsThe expession level of PCNA in the smooth m uscle cells (SMCs) on fibrous cap region was significantly elevated than that of the other three regions.The expession level of PCNA in the inflammatory cells ( ICs) on fibrous cap and shoulder region were significantly elevated than that of the other two regions.The amount of apoptosis in the SMCs on lipid-rich core wa s much more than that of the other three regions.The amount of apoptosis in the ICs on lipid-rich core was more than the other three regions.The expression leve ls of PCNA in fibrous cap and shoulder were significantly higher than TUNEL posi tive cell (P
