Cross-talk and molecular mechanisms between NMDA receptor and opioid receptor in opioid dependence
- VernacularTitle:阿片依赖病理过程中NMDA受体与阿片受体的相互作用及分子机制
- Author:
Ning WU
;
Jin LI
- Publication Type:Journal Article
- Keywords:
opioid dependence;
NMDA receptor;
opioid receptor;
protein kinase C
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Opioid dependence is based on compensatory adaptations in neurons following chronic exposure to opioids. Recent researches show antagonists of N methyl D aspartate (NMDA) receptors inhibit physical and psychic dependence on opioids. This review focuses on the interactions between opioid receptor system and NMDA receptor system, and on the molecular mechanisms of NMDA receptor contributing to opioid dependence. The clinical prospects of NMDA receptor antagonists and related substances on preventing and treating opioid dependence are aslo discussed.
