Interleukin-18 mRNA expression in vital organs in septic rats and its relation to endotoxemia
- VernacularTitle:脓毒症大鼠多器官白介素18表达及其与内毒素血症的关系
- Author:
Hongyun LI
;
Yongming YAO
;
Ning DONG
- Publication Type:Journal Article
- Keywords:
cecal ligation and puncture (CLP);
endotoxins;
interleukin-18;
sepsis
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change in interleukin-18 (IL-18) mRNA expression in cecal ligation and puncture (CLP) induced sepsis, and to investigate its potential role in the pathogenesis of endotoxemia. Methods Fifty-four Wistar rats were randomly divided into normal group (n=6), CLP group (n=36) and recombinant bactericidal/permeability increasing protein (rBPI 21) treatment group (n=12). Tissue samples from the liver, lungs and kidneys were collected to determine IL-18 mRNA expression. Meanwhile, tissue endotoxin level and the indexes of organ function were also measured. Results After CLP, endotoxin levels in the liver,lungs and kidneys were significantly increased, peaking at 2-12h (P
