Cytomegalovirus colitis causing toxic megacolon in a patient with focal segmental glomerulosclerosis.
- Author:
Pung KANG
1
;
You Sun KIM
;
Sung Mo JUNG
;
Eun Soon KIM
;
Jung Hwan LEE
;
Jeong Seop MOON
;
Haeng Il KOH
Author Information
1. Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. yousunk69@korea.com
- Publication Type:Case Report
- Keywords:
Megacolon;
Colitis;
Cytomegalovirus;
Glomerulosclerosis;
Focal
- MeSH:
Abdominal Pain;
Biopsy;
Colitis*;
Colitis, Ischemic;
Colon, Descending;
Colonoscopy;
Constipation;
Constriction, Pathologic;
Cytomegalovirus*;
Dilatation;
Ganciclovir;
Gastroenteritis;
Glomerulosclerosis, Focal Segmental*;
Hemorrhage;
Humans;
Megacolon;
Megacolon, Toxic*;
Middle Aged;
Ulcer
- From:Korean Journal of Medicine
2002;63(6):720-724
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cytomegalovirus is a frequent opportunistic pathogen in immunosuppressed patients and CMV colitis is one of its major complications. It usually presents as gastrointestinal ulceration with bleeding or perforation, but it can also take less common forms resembling many other entities, including viral gastroenteritis, ischemic colitis, intestinal pseudo-obstuction, toxic megacolon. We experienced a 49-year-old man with symptom of severe constipation and lower abdominal pain. He was diagnosed as having focal segmental glomerulosclerosis by renal biopsy, but he was an immunocompetent state. An abdominal X-ray showed marked dilatation of descending colon without air-fluid level. At colonoscopy and biopsy, he was diagnosed as having CMV colitis with focal stenosis. Treatment for two weeks with ganciclovir resulted in resolution of colitis, but stenosis was remained. We report a case of toxic megacolon and focal stenosis due to CMV colitis in a FSGS patient. It was not certain whether FSGS was related with immunosuppressive state.
