Desensitization of nicotinic receptors
- VernacularTitle:失敏态烟碱样受体
- Author:
Xiulan SUN
;
Gang HU
;
Ha WANG
- Publication Type:Journal Article
- Keywords:
desensitization;
nicotinic receptor;
acetylcholine;
choline
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinic acetylcholine receptors, a ligand-gated ion c hannels,mediates many important physiological processes. Chronic nicotine admini stration could desensitize nicotinic receptors. Many factors which modulate dese nsitization have been described, including different subunits, agonist, signal t ransduction and cellular microenivornment. The important physiological functions of desensitized receptors still remain controversial, may be modulate synaptic transmission,synapse plasticity and mediate self-protection.
