Proteins and signaling pathway in endotoxic effect
- VernacularTitle:内毒素作用中的蛋白质和信号通路
- Author:
Yuxin QIN
;
Qingzhu ZHANG
- Publication Type:Journal Article
- Keywords:
endotoxin;
Toll-like receptors(TLRs);
LBP;
CD14;
CD11/CD1 8;
signal transduction
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews the proteins and transduction pat hw ay in endotoxic action. Lipopolysaccharide-binding protein(LBP) binds and trans ports the LPS to its receptors, which include CD14 and CD11/CD18. Toll-like rec eptors(TLRs) is closely associated with transducting the signals into cytoplasm. Scavenger receptors are related to hepatic clearance on endotoxin .The intracel lular signal transduction is involved in several paths which finally leads to t he release of cytokines.
