Study on the antiplatelet effect of phospholipase C: release function and metabolism
- VernacularTitle:磷酯酶C抗血小板功能的研究Ⅱ——对血小板释放和代谢的作用
- Author:
Mingkai CHEN
;
Jianhua SONG
;
Xin WANG
;
Changgao WANG
;
Songbai SUN
;
Tao CHEN
- Publication Type:Journal Article
- Keywords:
phospholipase C;
TXA 2;
6-keto-PGF 1?;
bleedin g time
- From:
Chinese Pharmacological Bulletin
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the antiplatelet effect of PLC by de termining the concentration of TXB 2, 6-keto-PGF 1? and bleeding time( BT). METHODS TXB 2 and 6-keto-PGF 1? were detected by ra dioimmunity kit. Bleeding time were measured by routine methods. RESULTS Six doses of PLC can prolong BT significantly(P0 05). The inhibition on TXB 2 generation, of PLC 60 0～ 1 000 U?kg -1 with ADP revulsant, PLC 800～1000 U?kg -1 with AA revulsant and PLC 1 000 U?kg -1 with Collagen revulsant, is more significant than ASA (P
