Effect of gypenosides on hepatic function and fibrosis in rats with immune fibrosis
- VernacularTitle:绞股蓝总皂苷对免疫性肝纤维化大鼠肝功能和肝纤维化的影响
- Author:
Li WAN
;
Xingwang WAN
;
Jinhong HU
- Publication Type:Journal Article
- Keywords:
gypenosides;
immune fibrosis;
hepatic function;
liver fibrosis
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of gypenosides (GPs) on the hepatic function and fibrosis progression in Wistar rats with immune fibrosis. Methods: The model of immune fibrosis was established by injection of human albumin. Rats in treated group were also administered with 0. 5 mg GPs during 30 d human albumin attack. The hepatic function of rats was e-valuated by determining the levels of ALT, TBIL and TBA in serum. The progression of hepatic fibrosis was evaluated by the levels of HA, PC Ⅲ and LN by radioimmunoassay (RIA) and confirmed by rats tissue pathology analysis. Results: Albumin injection significantly elevated the levels ALT, TBIL, TBA, HA, PCⅢ(P
