Effect of botulinum toxin-A on lower esophageal sphincter in dogs
- VernacularTitle:A型肉毒毒素对犬下食管括约肌的作用
- Author:
Bin WANG
;
Zhongbing ZHANG
;
Xiaohong GU
;
Yueliang LU
- Publication Type:Journal Article
- Keywords:
botulinum toxin-A;
lower esophageal sphincter;
acetylcholine;
acetylcholinesterase;
achalasia
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT] Objective: To investigate the effect of botulinum toxin-A (BTA) on lower esophageal sphinctor (LES) in dogs,providing scientific base for treating achalasia with BTA. Methods:BTA was endoscopically injected into the LES in 10 dogs,and saline injection was taken as control group(10 dogs). LES pressure was measured before and after injection. Contents of Ach and activity of AchE were determined in LES samples. By means of Karnovsky-Roots technique,ultrastructure of nerve terminal and vesicles containing Ach were studied under light and transmission electronic microscopy. Results:LES pressure obviously decreased in BTA-treated dogs after injection (P
