Effects of intracerebral ventricular GLP-1(7-36) on blood glucose and its regulatory hormones in rats
- VernacularTitle:脑室给予胰升糖素样肽GLP－1（7－36）对大鼠血糖及血糖调节激素的影响
- Author:
Yongmei ZHAO
;
Hongwei QI
;
Wenkai TONG
- Publication Type:Journal Article
- Keywords:
GLP-1(7-36) Insulin Glucagon
- From:
Chinese Journal of Diabetes
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
After intracerebral ventricular administration of GLP-1 in NS or 30% glucose to rats,their effects on blood glucose and glucose regulatory hormones were observed. The results demonstrated:1. Intracerebral ventricular administration of GLP-1 in NS didn't influence plasma stucose, insulin and glucagon secretion.2. Intracerebral ventricular administration of GLP-1 in 30% glucose increased plasma glucose concentration significantly and decreased insulin concentration,but no change of glucagon concentration. This experiment showed that GLP-1 might participate in CNS regulation of pancreatic islet hormonesecretion.
