Effects of oral premedication with clonidine on stress response during tracheal extubation
- VernacularTitle:可乐定对气管拔管患者应激反应的影响
- Author:
Biming SHI
;
Yonggong REN
;
Xueping ZHANG
;
Yali LI
- Publication Type:Journal Article
- Keywords:
pharmacodynami cs;
tracheal extubation;
stress;
clonidine;
premedication
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of premedication with clonid in e on the concentrations of catecholamine (CA), angiotention Ⅱ (AⅡ), cortisol a nd carbohydrate metabolism during tracheal extubation. METHODS: Twenty-two patients scheduled for general anesthesia with tracheal intubation were randomly divided into two groups: clonidine group and control group. Oral p remedication with clonidine 5 ?g?kg -1 was taken in clonidine group 6 0 min before anesthesia induction in addition to some common premedication in bo th groups. The change of hemodynamics,arterial plasma concentrations of CA, A Ⅱ, cortisol, blood sugar and lactic acid were measured before anesthesia, befor e intubation and 1,2,5, 10 min after tracheal extubation, respectively. RESULTS: The levels of CA, AⅡ, cotisol, blood sugar and lactic acid were significantly increased during tracheal extubation in both groups,but the levels in control group were higher than those in clonidine group. The change of hemodynamics was more stable in clonidine group than that in control group. CONCLUSION: Oral premedication with clonidine can alleviate stress response during tracheal extubation.
