Protective effects of dexamethasone against ototoxicity in guinea pigs
- VernacularTitle:地塞米松对庆大霉素和丁胺卡那霉素所致豚鼠耳毒性的保护作用
- Author:
Xinbo ZHU
;
Xiaodong JIN
;
Miaowu DONG
;
Dan LIN
- Publication Type:Journal Article
- Keywords:
dexamethasone;
gentamycin;
am ikacin;
ototoxicity;
guinea pigs
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of dexamethasone agains t ototoxicity of aminoglycoside antibiotics in guinea pigs. METHODS: Guinea pigs were divided into five groups. Group One: gentamycin, im; Group Two: amikacin, im; Group Three: gentamycin+ dexamethasone, im; Group Four: amika cin+ dexamethasone,im; Group Five: NS, im, all for two weeks. After three weeks, all animals were examined including tympanic mucous membrane reaction, nystagmu s depression rates and cochleae morphology. RESULTS: In Group Th ree and Four, the changes of morphology were slighter than those in Group One an d Two. CONCLUSION: Dexamethasone can weaken ototoxicity of amino glycoside antibiotics.
