Influence of thyroid function on metabolisms of diazepam and nordiazepa m in rats
- VernacularTitle:甲状腺功能对地西泮及其代谢产物在大鼠体内代谢的影响
- Author:
Hanxiong DAN
- Publication Type:Journal Article
- Keywords:
pharmacokinetics;
thyroid;
diazepam;
nordiazepam;
drug metabolism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the influence of thyroid function on metabol is m of diazepam and nordiazepam in rats. METHODS: HPLC method was used to determine the blood concentrations of diazepam and nordiazepam from rats with different thyroid function. RESULTS: Diazepam was metaboli zed rapidly in the rats with hyperthyroidism, the Cmax and AUC were decreased, a nd the T 1/2 was cut short, but it showed an opposite resul ts in the rats with hypothyroidism. While pharmacokinetic parameters of diazepam were opposite in comparison with nordiazepam. CONCLUSION: Metab olism of diazepam increases in rats with hyperthyroidism.
