Relationship between PCNA,nm23-H1 expression and prognostic factors in supratentorial astrocytoma
- VernacularTitle:幕上星形细胞瘤PCNA和nm23-H1表达与相关预后因素分析
- Author:
Wei FENG
;
Bingquan CHENG
;
Shuchai ZHU
- Publication Type:Journal Article
- Keywords:
Astrocytoma/surgery;
Astrocytoma/radiotherapy;
Proliferating cell nuclear antigen;
Neoplasm metastasis genes, nm23-H1;
Prognosis
- From:
Chinese Journal of Radiation Oncology
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of proliferating cell nuclear antigen (PCNA), metastasis-related gene nm23-H1 in supratentorial astrocytomas, and analyze the prognostic factors and the relationship between PCNA expression, nm23-H1 expression and clinical, MRI features.Methods From November 1994 to December 1998, 52 pathologically proved astrocytoma patients with complete clinical data were analyzed. The expressions of PCNA and nm23-H1 were detected by streptabitin peroxidase (SP) immunohistochemical method. Clinical and MRI data were collected and analyzed by Cox proportional hazard model .Results There was a significant difference in the expressions of PCNA and nm23-H1 in the lesion and their adjacent tissues (P
