La accumulation and microstructure change of leg bones of rats fed with La(NO_3)_3 in low dosage for a long term
- VernacularTitle:低剂量长期饲喂La(NO_3)_3后La在大鼠骨中的蓄积及骨微结构的改变
- Author:
Rongchang LI
;
Huiwen YANG
;
Kui WANG
- Publication Type:Journal Article
- Keywords:
Lanthanoid series elements;
Bone density;
Rats
- From:
Journal of Peking University(Health Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study La accumulation and microstructure change of leg bones of rats fed with La(NO 3) 3 in low dosage for a long term. Methods: After the rats were fed by La(NO 3) 3 in dosage of 2 mg?kg -1 ?d -1 for 6 months, the contents of La and Ca,P in the leg bones were determined by ICP MS and spectrophotometry; the microstructure changes of the leg bones were investigated by electron microscopy and X ray powder diffraction. Results: In the leg bones of tested rats, the contents of La and P increased greatly, and those of Ca did not change obviously, so that Ca/P ratio values decreased in comparison with the control group. Conclusion: La was accumulatied in the rat leg bones and the change of bone microstructure induced after the rats were fed with La(NO 3) 3 in low dosage for a long term.
