ANESTHESIA AND MYOCARDIAL PROTECTION DURING CORONARY BYPASS SURGERY WITHOUT CARDIOPUL-MONARY BYPASS: COMPARISON BETWEEN PROPOFOL AND FENTANYL
- VernacularTitle:非体外循环冠状动脉旁路移植术的麻醉与心肌保护——丙泊酚与异氟烷的比较
- Author:
Weidong MI
;
Hong WANG
;
Wentong DONG
- Publication Type:Journal Article
- Keywords:
coronary artery bypass grafting;
propofol;
isoflurane;
troponin I;
interleukin-6
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the possible protective effect of isoflurane and propofol on myocardium during off pump coronary artery bypass grafting (CABG) surgery. Methods Twenty-six patients undergoing elective CABG without cardiopulmonary bypass were allocated into propofol group (n=13) and isoflurane group (n=13). Anesthesia was performed in propofol group with propofol plus fentanyl, while isoflurane and fentanyl were used in isoflurane group. Artery blood samples were collected before induction of anesthesia, and during and after the surgery. Plasma troponin I (cTnI), creatine kinase-MB (CK-MB), interleukin-6 (IL-6), and lactate concentrations were determined respectively. Results At the 4 hours after operation, plasma level of cTnI was significantly increased in both groups, and no significant differences were found between them. Compared with baseline values, IL-6 in propofol group showed no significant changes at each endpoint. However, IL-6 values in isoflurane group were significantly higher than those in propofol group during and after surgery (P
