Relation of hepatitis C virus level and genotypes to response to interferon treatment
- VernacularTitle:丙型肝炎病毒负荷和基因型与干扰素治疗应答关系的研究
- Author:
Kun LI
;
Lihui WANG
;
Jun YE
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus Genotype Interferon
- From:
Chinese Journal of Practical Internal Medicine
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between HCV genotype and its level and the response to interferon (IFN).Methods HCV genotypes were detected by type-specific primes modified PCR assay.HCV-RNA levels were determined by branched DNA(bDNA) singnal PCR amplification fluorescence assay.The patients with chronic hepatitis C virus infection treated with IFN ? were divided into different groups according to genotypes or levels of HCV.Result Patients with pre-treatment HCV levels10 9 eq?L -1 showed partial responses (28 6%) or no responsces (28 6%).Stasistical analysis showed significant difference (P
