Expression of P27~kipl and mutant P53 protein in thyroid tumors
- VernacularTitle:P27~(kipl)和突变型P53蛋白在甲状腺肿瘤中表达的意义
- Author:
Peng LI
;
Houxiang LI
- Publication Type:Journal Article
- Keywords:
P27kipl;
P53;
thyroid carcinoma;
thyroid adenoma;
immunohistochemistry
- From:
Academic Journal of Second Military Medical University
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of P27kipl and mutant P53 protein in thyroid tumors, and to understand the relationship between the biological behavior and prognosis of benign and malignant thyroid tumors. Methods: We used S-P immunohistochemical technique to study the expression of P27kipl and mutant P53 protein in 60 cases of thyroid tumors, including 40 cases of malignant tumors and 20 cases of benign tumors. Categorical data were analyzed by using X2 tests. All reported significance levels were two-tails. The software system used for statistical analysis was SPSS10. 0. Results: In benign and malignant tumors, P27kipl protein positive expression was detected in 18 of 20 benign cases (90. 0%) and 24 of 40 malignant cases (60. 0% ) respectively(P P
