Role of ERK/AP-1 pathway in the differentiation induced by DADS on human gastric caner cell
- VernacularTitle:DADS诱导人胃癌细胞分化作用中ERK/AP-1通路的改变
- Author:
Hui LING
;
Ying SONG
;
Tiebing ZENG
;
Jingping YUAN
;
Qi SU
- Publication Type:Journal Article
- Keywords:
stomach neoplasm;
diallyl disulfide(DADS);
differentiation;
ERK/AP-1
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the role of ERK/AP-1 pathway in the differentiation induced by diallyl disulfide (DADS) on human gastric cancer MGC803 cell. METHODS Immunocytochemical staining and morphometric quantitative analysis detected the expression of c-fos and c-jun;Western Blot which measured the activation of ERK was analyzed to elucidate the possible mechanism of DADS-induced human gastric cancer cell differentiation. RESULTS Immunocytochemical staining and morphometric quantitative analysis indicated that expression of c-fos and c-jun reduced(P
