Effects of mitochondrial ATP-sensitive potassium channel opener on the structures and functions of the mitochondria
- VernacularTitle:心肌线粒体ATP敏感性钾通道开放保护线粒体结构和功能
- Author:
Wei LIU
;
Haochun WANG
;
Yanfang ZHANG
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
diazoxide;
mitochondria;
respiration control rate;
membrane lipid fluidity;
phosphlipid
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To evaluate the effects of diazoxide on the structures and functions of the mitochondria after hypoxia injury. METHODS A myocardial hypoxia injury model on rat is established by subcutaneous injection of isoproterenol (ISO) 5 mg?kg -1. The degree of oxidative phosphorylation, membrane lipid fluidity (LFU), phospholipidase A 2 activity, and phosphlipid content of mitochondria were observed after hypoxia injury. RESULTS Compared with the controls, the levels of RCR, LFU and phosphlipid content were decreased 20.8% (P
