Effect of BCEF0083 on sleep-wakefulness cycle and behaviour in chronic unpredictable stress model of depression in rats
- VernacularTitle:BCEF0083对慢性应激抑郁模型大鼠睡眠及行为的影响
- Author:
Yan CHENG
;
Liang MING
;
Lanlan ZHOU
;
Gongliang ZHANG
;
Fang JIDONG
- Publication Type:Journal Article
- Keywords:
depression;
behavior;
polysomnography;
sleep;
rat;
BCEF0083
- From:
Chinese Pharmacological Bulletin
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of bioactive compounds from entomogenous fungi (BCEF0083) on sleep-wakefulness cycle and behaviour in chronic unpredictable stress model of depression in rats. METHODS The effect of BCEF0083 on sleep-wakefulness cycle and behaviour was examined in the chronic unpredictable stress model of depression in rats. Stereotaxic and polysomnography were used to record the sleep-wakefulness cycle. The behaviour of rats was tested in the open field. RESULTS BCEF0083 increased ambulation and rearing score of chronic unpredictable stressed rats in the open field. BCEF0083 attenuated REMS percent and latency in chronic stressed rats obviously. CONCLUSION BCEF0083 can ameliate sleep-wakefulness cycle and behaviour in chronic unpredictable stress model of depression in rats.
