Interleukin-8 and tumor necrosis factor-? are contributing to airw ay inflammation in rat model of chronic obstructive pulmonary disease
- VernacularTitle:慢性阻塞性肺疾病大鼠肺内白细胞介素-8和肿瘤坏死因子-?与气道炎症的关系研究
- Author:
Yong ZHANG
;
Deyun CHENG
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Interleu kin-8;
Neutrophil;
Tumor necrosis factor-?
- From:
Chinese Journal of Respiratory and Critical Care Medicine
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of interleukin-8(IL-8) in the pathogene sis of COPD MethodsRat model of chronic obstructive pulmonary disease(COPD) was established by exposure Wistar rats to cigarette smoke dai ly for 120 days Total cell counts and neutrophil counts in BALF were examined The levels of IL-8 and tumor necrosis factor-?(TNF-?) in BALF and serum wer e measured with ELISA Lung tissue section stained by HE was observed to study t he morphological alternations and MLI,MAN and PAA were measured Result sMLI and PAA in COPD rat were higher than those in control group (P
