The electrophysiological properties of visual cortical neurons in binocular form-depri-vated rats
- VernacularTitle:双眼形觉剥夺对大鼠视皮层神经元电生理特性的影响
- Author:
Huimin FAN
;
Zhengqin YIN
;
Pengfen GAO
;
Shijun WANG
- Publication Type:Journal Article
- Keywords:
LTP;
form-deprivation;
plasticity;
whole cell recording
- From:Journal of Third Military Medical University
2003;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the electrophysiological properties of neurons in visual cortex of binocular form-deprivated rats during the developmental stages and to explore the synaptic and cellular mechanisms of plasticity in the visual cortex. Methods Whole cell patch clamp technique was applied to the visual cortex slices prepared from 61 Wistar rats of both genders, which were divided into two groups; control group and binocular form-deprivation (BFD) group. Excitatory postsynaptic currents (EPSCs) and long term potentiation (LTP) of the neurons were recorded. Results (1) The percentage of silent response in BFD group was significantly higher than that in the control group(P
