Research of the expression of Na+/dicarboxylate cotransporters in renal tissue of IgA nephropathy
- VernacularTitle:钠依赖二羧酸转运蛋白在IgA肾病患者肾组织表达的研究
- Author:
Suozhu SHI
;
Xiangmei CHEN
;
Xueguang ZHANG
;
Jie WU
- Publication Type:Journal Article
- Keywords:
Na~+/dicarboxylate cotransporters;
IgA nephropathy
- From:
Chinese Journal of Nephrology
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of human Na+/dicarboxylate cotransporters (NaDC)in IgA nephropathy,and to discuss its role in IgA nephropathy. Methods Thirty-four cases of IgA nephropathy diagnosed by renal biopsy were divided into five grades according to the degree of pathological change of IgA nephropathy,and their tubulointerstitial lesions were semi-quantitatively analyzed. Changes of the expression of NaDC1 and NaDC3 in kidney were observed by using immunohistochemistry,and analyzed with clinical data by correlation. Results Tubulointerstitial lesion exacerbated with the progress of pathological change in IgA nephropathy. In the cases of Ⅳ and Ⅴ grade,24 h urinary protein,serum creatinine,urinary NAG enzyme were increased,and urinary osmotic pressure was decreased,as compared with the cases of Ⅰ-Ⅲ grade( P
