Expression of bone morphogenetic proteins-4 in human gastric cancer
- VernacularTitle:胃癌组织中骨形成蛋白4的表达
- Author:
Ximei CHEN
;
Weifen XIE
;
Zhirong WANG
;
Fengshang ZHU
;
Guoyu CHEN
- Publication Type:Journal Article
- Keywords:
bone morphogenetic proteins;
stomach neoplasms;
immunohistochemistry
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the expression level of bone morphogenetic proteins-4 (BMP-4) and the relationship between the expression of BMP-4 and the clinical/pathological parameters in patients with gastric cancer. Methods:Using im-munohistochemical staining technique ,expressions of BMP-4 were investigated in different tissues from 90 gastric cancer specimens and 30 specimens from normal gastric mucosa as control. ResultS:The positive rate of BMP-4 was 23. 3% (21/90) in gastric cancer and 3. 3% (1/30) in normal gastric mucosa. The expression of BMP-4 in gastric cancer was closely related with locus, serosa infiltration,cell differentiation and lymph node metastasis (P
