Progress in the study of glutathione in Parkinson's disease
- VernacularTitle:谷胱甘肽在帕金森病治疗中的研究进展
- Author:
Jun HU
;
Gang HU
- Publication Type:Journal Article
- Keywords:
pharmacology;
review;
Parkinson's disease;
oxidative stress;
glutathione;
neurodegenerative disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, there is increasing evidence that the pathogenesis of Parkinson's disease (PD) may involve the more generation of reactive oxygen species, and investigations on patients have shown that PD is under a status of oxidative stress. The defense against the toxic effects of reactive oxygen species is an essential task within the brain. An important component of the cellular detoxification of reactive oxygen species is the antioxidant glutathione. Consequently, it seems reasonable to propose that increase of brain concentrations of glutathione including glutathione analogs or precursors could be very effective in diminishing the cumulative effects of oxidative damage, and have been investigated as potential therapeutic targets in the treatment and prevention of PD or other neurodegenerative disease.
