EXPERIMENTAL STUDY ON THE PREPARATION AND TRANSPLANTATION OF COMPOSITE SKIN COMPOSED OF ACELLULAR DERMIS AND KERATINOCYTES
- VernacularTitle:无细胞真皮复合皮制备及移植的实验研究
- Author:
Wang LIU
;
Shichu XIAO
;
Jingning HUAN
- Publication Type:Journal Article
- Keywords:
cell culture;
dermis;
biologic dressing;
skin transplantation healing
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
To study the method of preparing the composite skin composed of keratinocytes and acellular dermis, and to investigate the efficacy as well as its histological changes after being grafted on wounds of athymic mice. Compared with keratinocyte sheet grafting, the wounds grafted with composite skin had better healing rate, appearance and less wound contraction rate. Moreover, histological examination revealed fully differentiated epidermis, organized proliferated collagen fibres, and distinct reconstruction of epidermis-dermis junction in composite skin group, with absence of acute immuno-rejection response. As a new kind of skin substitutes, the composite skin can improve the quality of wound healing.
