GENE EXPRESSION OF COLLAGEN TYPE Ⅰ AND TYPE Ⅲ IN TISSUE OF LOW COMPLIANT BLADDER

VernacularTitle:大鼠低顺应性膀胱组织中Ⅰ型、Ⅲ型胶原蛋白基因的表达
Author: Nan LIU ; Bo SONG ; Xiyu JIN
Publication Type:Journal Article
Keywords: bladder; obstruction; collagen; reverse transcriptase polymerase chain reaction
From: Medical Journal of Chinese People's Liberation Army 2001;0(10):-
CountryChina
Language:Chinese
Abstract: Objective To investigate the alteration in gene expressions of collagen type Ⅰ and type Ⅲ in tissue of obstructive low compliant bladder of rats. Methods Gene expressions of collagen type Ⅰ and type Ⅲ in the rat bladder tissues were evaluated with RT-PCR. Results The gene expressions of collagen type Ⅰ and type Ⅲ in smooth muscle of low compliant bladder were up regulated, but the level of type Ⅲ gene expression was stronger than that of the type I. Conclusion Collagen type Ⅲ and Ⅰ gene expression was upregulated in tissue of obstructive low compliant bladder of rats. Up regulation of collagen gene expression was related to low compliant bladder after obstruction.