STUDY ON THE EFFECT OF REMIFENTANIL ON THE EXPRESSION OF APOPTOSIS FACTORS IN LUNG IN RATS WITH HEMORRHAGIC SHOCK
- VernacularTitle:雷米芬太尼对失血性休克大鼠肺内凋亡因子表达影响的实验研究
- Author:
Ying GUO
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
shock, hemorrhagic;
lung injuries;
remifentanil;
apoptosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the modulating effects of remifentanil on the expression of apoptosis factors during acute lung injury as a result of hemorrhagic shock, we observed the expression of C-Jun, Bax, Bcl-2 in lung with immunohistochemistry in rats with hemorrhagic shock. Methods Hemorrhagic shock model was replicated with modified Wigger's method in healthy SD rats. Seventy-two rats were randomized into three groups: sham resuscitation, resuscitation with lactated Ringer′s solution, and fluid resuscitation with remifentanil. Positive rates of C-Jun, Bax, Bcl-2 were assayed in the lungs at different time points: preshock, shock, 2 hours after resuscitation, and 4 hours after resuscitation. Results ①The model of acute lung injury subsequent to hemorrhagic shock was reproduced in rats. ②The expression of Bcl-2 elevated slowly in three groups, while the expression of Bax elevated rapidly, and there were significant differences between the value of baseline and those of other time points (P
