Effect of preoperative regional artery chemotherapy on gastric carcinoma
- VernacularTitle:胃癌术前介入化疗的病理分析
- Author:
Wen HUANG
;
Yu ZHAO
;
Ling LUO
- Publication Type:Journal Article
- Keywords:
gastric cancer;
preoperative regional artery chemotherapy;
pathological study;
apoptosis
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of preoperative regional artery chemotherapy (PRACT) on gastric carcinoma. Methods Celiac arteriography was performed by transfemoral artery catheter according to Seldinger's method and superselective catheterization proceeded to the supplying artery of focus of lesion. Antineoplastic agents of Fluorodeoxyuridine (FUDR)(0.8 g/m 2), epirubicin(40 mg/m 2), oxaliplatin(80 mg/m 2) were infused into regional artery by a single administration. The specimens from 14 cases of gastric carcinoma(GC) who received PRACT were separated into pre operation group and post operation group. Both microscopic study to observe the necrosis of cancer cell and TUNEL(TdT mediated dUTP nick end labeling) method to detect the state of apoptosis were performed respectively in the two groups. Correlation of apoptosis index (AI) between the two groups, as well as correlation between the situation of necrotic tumor cell and the blood vessel, was analyzed. Results The severity of the necrosis of tumor cell was significantly higher in the PRACT group than that in the untreated group ( P
