EFFECT OF CURCUMIN ON PROLIFERATION AND APOPTOSIS OF TK6 CELLS
- VernacularTitle:姜黄素对TK6细胞的增殖抑制和凋亡诱导作用研究
- Author:
Jianqing ZHANG
;
Lishi ZHANG
;
Ruish WANG
- Publication Type:Journal Article
- Keywords:
curcumin;
TK6 cell;
proliferation;
apoptosis
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of curcumin on proliferation and apoptosis of TK6 human diploid lymphoblastoid cells.Methods: MTT colorometric assay, 3H-TdR incorporation, cell cycle analysis were used to evaluate the effect on proliferation, and morphology microstructure. Flow cytometry was used to detect the effect on apoptosis induction on TK6 cell.Results: Curcumin could inhibit proliferation by blocking transition from G0/G1 to S phase, induce apoptosis in TK6 cells. The effective dose for proliferation inhibition and apoptosis induction is 20 ?mol/L.Conclusion: Apoptosis induction is one of important mechanisms for anti-mutagenic, anti-tumor action of curcumin.
